Author Login

Correspondence to Author:  Lis Paulino de Oliveira ¹; Beatriz de Luna Costa Pinheiro ²; Isabela Zanella Ramponi ³; Nathalia de Castro Fraga ³;Luiza Freitas Mello ³; Bruna Martinez Puglia ⁴; Ana Luiza Zampar Quintana Gomes ⁵; Larissa Caetano Faleiro ⁶;Giovana Casarini Yamashiro ⁷; Luiza Benicio Teodoro ⁷; Ana Laura Nogueira Ervilha ⁸; Ana Carolina Aparecida Reis ⁸; Cecília Marques Meirelles ⁸; Délio Tiago Martins Malaquias ⁹; Ana Carolina Passeli ⁹; Talita Quirino Lopes ⁹;Elis Consolin ⁹; Rafaela Gonçalves Bueno ⁹; Eliane Franklin ⁹; Aghata Abreu Mendes Faria ⁹; Viviane Ferrari Gomes ¹⁰; Rubens Rodrigues Tudela ¹¹; Thiago Augusto Rochetti Bezerra ¹². 

1. Doctor graduated from the University of Potiguar (UNP). Natal, Rio Grande do Norte.
2. Doctor graduated from the Nove de Julho University in São Bernardo do Campo and a postgraduate degree in Dermatology.
3. Doctor graduated from the Nove de Julho University in São Bernardo do Campo, São Paulo, Brazil.
4. Doctor graduated from the University of the City of São Paulo (Unicid), São Paulo, Brazil.
5. Medical student. Professor Edson Antônio Velano University (UNIFENAS) - Alfenas, Minas Gerais.
6. Medical student. Zarn College. Itumbiara, Goiás, Brazil.
7. Medical student. Nove de Julho University, São Bernardo do Campo, São Paulo, Brazil.
8. Medical student. FCMSJC - Humanitas. São José dos Campos, São Paulo, Brazil.
9. Medical student. Ribeirão Preto University. Guarujá, São Paulo, Brazil.
10. Medical student. Ribeirão Preto University. Ribeirão Preto, São Paulo, Brazil.
11. Medical student. São Judas. Cubatão, São Paulo, Brazil.
12. PhD in Medical Sciences. Ribeirão Preto Medical School. University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

DOI: 10.52338/aods.2025.4831

Abstract:

Introduction: Skin aging leads to loss of collagen, elasticity and facial volume, motivating the search for minimally invasive aesthetic procedures. Among the available strategies, collagen biostimulators have stood out as effective therapies for facial rejuvenation, promoting progressive dermal regeneration.
Objective: This systematic review aimed to analyze recent advances in the use of collagen biostimulators for facial rejuvenation in the practice of aesthetic dermatology.
Methodology: PubMed, Scopus, Web of Science and Embase were searched, including articles published between January 2019 and April 2025. Clinical studies, systematic reviews and meta-analyses that addressed the efficacy, safety and innovations in collagen biostimulators were included.
Results: 42 studies evaluating the use of poly-L-lactic acid (PLLA), calcium hydroxyapatite (CaHA) and polycaprolactone (PCL) in facial rejuvenation were selected. PLLA demonstrated efficacy in progressive dermal remodelling, CaHA provided immediate volumization and subsequent biostimulation, while PCL exhibited superior durability of clinical effects. All biostimulators showed favorable safety profiles, with a high patient satisfaction rate.
Conclusion: Collagen biostimulators have established themselves as essential elements in minimally invasive facial rejuvenation, offering natural and long-lasting results. Personalization of treatments and technical mastery are essential to optimize efficacy and minimize complications. Future research should focus on multicenter, long-term clinical trials to strengthen the available evidence.

Keywords:Collagen biostimulators; Facial rejuvenation; Aesthetic dermatology; Poly-L-lactic acid; Calcium hydroxyapatite; Polycaprolactone.

Citation:

Thiago Augusto Rochetti Bezerra, Recent Advances in Collagen Biostimulators for Facial Rejuvenation: A Systematic Review in Aesthetic Dermatology. Annals of Dermatological Science 2025.