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Authors:  Gabriel Buendía Bordera¹, Francisca Rubio Toral² , Anna Serrabou³, Ariadna Gamboa Roget⁴, Maria Llanos Pérez González⁵, Maria Begoña García Díaz⁶, Sandra Expósito González⁷ .  

1. Scientific Director, Instituto de Fotomedicina, Centro Médico Teknon, Barcelona. Spain

2. Aesthetic Doctor, Toral Clinic Barcelona, Barcelona. Spain

3. Aesthetic Doctor, Esthetic BCN, Barcelona. Spain

4. Dermatologic Doctor, Instituto de Fotomedicina, Centro Médico Teknon, Barcelona. Spain

5. Medical Scientific Liaison, Toskani, Santa Eulalia de Ronçana. Spain

6. Technical Director, Toskani, Santa Eulalia de Ronçana. Spain

7. Clinical Study Coordinator, Toskani, Santa Eulalia de Ronçana. Spain

† These authors contributed equally to this work

Abstract:

Hyaluronic acid (HA), regardless of its molecular weight, presentation and route of administration, is currently among the products most in-demand by our clients for the prevention and treatment of skin ageing in aesthetic medicine clinics.
Among the injectables marketed for use in mesotherapy, the very high molecular weight non-cross-linked HA (VHMWHA ≈3000 kDa), TKN HA3®, is classified as a dermabooster that is characterized by its revitalizing, stimulating and regenerative properties: acting directly on the dermis, stimulates fibroblasts, promoting de novo collagen and elastin synthesis and thus improving the properties of the components of the extracellular matrix. It is also known for its hygroscopic properties, which hydrate the collagen and elastin fibres present in the skin, thus improving its elasticity and turgor. The molecular weight of non-cross-linked VHMWHA is very similar to that of the main type of HA produced by the skin, which explains why no side effects have been reported to date.
To demonstrate the efficacy and safety of VHMWHA for improvement the elasticity in the skin, patients who had received a four-point injection of VHMWHA were selected, specifically TKN HA3®, in the first half of 2023, and had three sessions at three-week intervals. A total of 119 male and female volunteers were recruited. Theresults showanimprovementinskinelasticityasmeasured by a Cutometer® in 86% of patients, and an improvement in Global Aesthetic Improvement Scale (GAIS) score assessed by the patients and researcher, showing an overall improvement of the skin of 95.7% and 83.7%, respectively. Dermal injection of VHMWHA with molecular weight ≈3000 kDa was shown to be safe and effective in improving skin elasticity.

Keywords:

Treatment, prevention, anti-ageing, ageing, elasticity, noncross-linked hyaluronic acid, very high molecular weight hyaluronic acid.

Citation:

Maria Llanos Pérez González. Retrospective controlled study of the efficacy of very high molecular weight hyaluronic acid (VHMWHA) noncross-linked as a dermabooster for the improvement of elasticity in the skin. Annals of Dermatological Science 2024.