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Journal of Psychological Medicine, 2025, Volume 10, Issue 1, Pages: 1-8
Amantadine’s Potential To Mitigate GlutamateInduced Toxicity In Pyramidal Cells Of The Juvenile Rat Brain Cortex.
Correspondence to Author: Ahmed S. Ahmed1*,Mark M. Rohn2,Asim S. Khan3.
1. Biomedical Sciences department, College of Medicine, Gulf Medical University. Ajman 4184, United Arab Emirates.
2. Biochemistry & Molecular Biology Department, Medical research institutes in Texas. Texas 78712, USA.
3. Department of Pharmacotherapeutics, College of Pharmacy, Immam Abdulrahman University. Dmmam 8273, KSA.
Abstract:
Glutamate (Gt) neurotoxicity is implicated in a wide range of neurological conditions, with the loss of glutamate transporters leading to intracellular Gt accumulation. Amantadine (AMn), a non-competitive N-Methyl-D-aspartate (NMDA) antagonist, can partially inhibit Gt transporters and modulate Protein Phosphatase 2A subunit B (PP-2A-B) activity. This study explores the potential of early-life AMn administration to counteract Gt-induced changes in the cerebral cortex using a rat model. Our findings indicate that AMn can reverse Gt-induced structural alterations in the brain cortex and enhance PP-2A activity. Additionally, PP-2A-B activity in the AMn+Gt-treated group was comparable to control levels. Furthermore, AMn administration reduced the apoptotic index in Gt-treated individuals. We propose that the severe histopathological changes observed in the Gt group may be attributed to decreased PP-2A expression, disrupting the balance between phosphatase and protein kinase activities and resulting in a strong positive TUNEL reaction. This study provides a concise overview of the current understanding of PP-2A-B’s role in Gt-induced neurotoxicity and AMn treatment while highlighting amantadine’s potential as a therapeutic agent.
Keywords: Amantadine; Glutamate; cerebral cortex; PP-2A.
Citation:
Dr.Ahmed S. Ahmed, Amantadine’s Potential To Mitigate GlutamateInduced Toxicity In Pyramidal Cells Of The Juvenile Rat Brain Cortex. Journal of Psychological Medicine 2025.
Journal Info
- Journal Name: Journal of Psychological Medicine
- Impact Factor: 1.9
- ISSN: 2998-9248
- DOI: 10.52338/jopm
- Short Name: JOPM
- Acceptance rate: 55%
- Volume: 7 (2024)
- Submission to acceptance: 25 days
- Acceptance to publication: 10 days
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