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Correspondence to Author: Zuowei Zou¹⁺, Luhua Xia²⁺,Fengsai Bie³, Zhian Li³,Zhanfei Dong², Lixiang Huang⁴,Rongfeng Chen^3*,Shijun Zhao⁵. 

¹Department of Nuclear Medicine, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² Department of Nuclear Medicine, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, China.
³National Center for Occupational Safety and Health, National Health Commission of the People’s Republic of China, Beijing, China.
⁴Department of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
⁵Department of Diagnostic Radiology, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

DOI: 10.52338/jopm.2025.4361

Abstract:

Background:Systematic evaluation of the effects of psychological nursing on alleviating anxiety and depression in patients undergoing iodine-131 isolation therapy following thyroid cancer surgery.
Methods: A meta-analysis was conducted to investigate the impact of psychological nursing on anxiety and depression in patients undergoing postoperative iodine-131 isolation therapy for thyroid cancer. Literature searches were performed across eight databases for peer-reviewed articles published between 2010 and 2023 that discussed the impact of psychological care on anxiety and depression in patients. Data extraction focused on mean differences (MD), standard deviations (SD), and 95% confidence intervals (95% CI) of anxiety scores (SAS) and depression scores (SDS) between the experimental group receiving psychological nursing and the control group without it. Study quality was appraised using the Cochrane Risk of Bias Assessment Tool in Rev Man 5.4 software, which also supported statistical analyses. Sensitivity analysis was performed with STATA 14.0 software. Additionally, publication bias was evaluated using Begg’s test and Egger’s test within the same software.
Results: Twelve studies involving 1004 patients undergoing iodine-131 treatment for thyroid cancer were included, with 502 patients in the experimental group and 502 patients in the control group. The results showed that compared to the control group, the experimental group had a significant decrease in SAS scores (MD=-8.18, 95% CI [-9.54, -6.838], P<0.05) and SDS scores (MD=-8.49, 95% CI [-9.93, -7.04], P<0.05), indicating a statistically significant difference.
Conclusion: Psychological care has been shown to be effective in alleviating anxiety and depression in patients undergoing postoperative iodine-131 isolation therapy for thyroid cancer, warranting its clinical promotion and application.

KeyWords: Psychological nursing, I-131 therapy, anxiety, depression, meta-analysis.

Citation:

Dr.Rongfeng Chen, Impact Of Psychological Nurse On Anxiety And Depression In Thyroid Cancer Patient Treated With Iodine-131 Isolation: A Systematic Review And Meta-Analysis. Journal of Psychological Medicine 2025.