Author Login

Correspondence to Author: Anea Paolini, Masimo Vgnoli, Nicla Benabò, Amnda ianchi, Roerto Tmbrro, Mria ristina Pinelli, Franesca Dl Sgnore, Andea De Bons, Martia Rosto, Francesco Colivignarelli, Cela Dstefano,I aria Ceasoli. 

Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.

Abstract:

Cats are frequently uncooperative and easily agitated. In the feline species, sedatives are frequently employed for even simple clinical and diagnostic procedures. The objective of this research is to evaluate the effect of intrarectal (IR) injection of a combination of midazolam, ketamine, and dexmedetomidine as opposed to the intramuscular (IM) one. Twenty cats participated in a clinical trial that was blinded and randomized. The cats underwent an ophthalmological and clinical checkup. Dexmedetomidine 0.003 mg kg−1, ketamine 4 mg kg−1, and midazolam 0.4 mg kg−1 were given to the IR group; similarly, the IM group was given dexmedetomidine 0.003 mg kg−1, ketamine 2 mg kg−1, and midazolam 0.2 mg kg−1.One hour before to sedation, a Shirmer tear test I (STT-I) was performed, and two, ten,20′, 30′, 40′, and 80′ after the medication is administered. Additionally, the response to the administration of STT-I was assessed. For every time point examined, the IM group produces fewer tears on average than the IR group. The cats in the instant messaging group reacted less to the administration of STT-I. According to this study, sedatives given by the IR route may have a less common impact on tear generation than those given by the IM method. In any event, using eye lubricant is advised.
Summary: :Sedatives are increasingly being used in veterinary medicine to carry out diagnostic and clinical operations. A number of anesthetic medications reduce the formation of tear flow. The therapeutic effectiveness of sedative and hypnotic drugs for novel and atraumatic delivery routes has drawn more attention in recent years. The generation of tear films in cats has never been studied.obtained sedatives using the intrarectal (IR) route. This study compares the clinical effects of an IR versus intramuscular (IM) administration of a combination of dexmedetomidine, ketamine, and midazolam on tear film flow.

Keywords:Cats, Tear Generation, Dexmedetomidine, Ketamine, Midazolam, Sedation, Intrarectal Route, Intramuscular Route.

Citation:

Dr.Anea Paolini, A Randomized Controlled Trial Comparing The Intrarectal And Intramuscular Impact Of A Combination Of Dexmedetomidine, Ketamine, And Midazolam On Cat Tear Production. Journal of Veterinary Science and Research 2025.