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Correspondence to Author: Jin Li^1*, Chao Zhao¹ 

¹Department of Urology, 983 Hospital, Joint Logistic Support Force, Tianjin 300142, China.

DOI: 10.52338/tajokd.2025.4257

Abstract:

Background: Important urological diseases with possible overlapping etiologies included urinary calculi and renal cancer. Although both disorders are associated with metabolic abnormalities and chronic inflammation, their cooccurrence and common molecular pathways are yet poorly investigated.
Objectives: This investigation examined the urinary calculi’s clinical, biochemical and molecular relationships with renal cancer.
Methods: Analyzing a cohort of 526 patients, demographic information, clinical features and laboratory markers was conducted. Key kidney cancer-related genes; VHL, PBRM1, and MET, were subjected to molecular studies. Structural protein models were created from RCSB PDB data and integrated bioinformatics techniques analyzed protein expression and mutation frequency.
Results: With significant p values, all covariates, obesity (OR = 2.1), hypertension (OR = 1.8), diabetes (OR = 1.7), and hypercalciuria (OR = 2.3) were found as major risk factors for the co-occurrence of urinary calculi and renal cancer. Frequent mutations in VHL (23.6%), PBRM1 (20.9%) and MET (18.6%), were found by molecular analysis. Indices of proinflammatory environment were shown by elevated indicators of oxidative stress (ROS, MDA) and inflammation (CRP, IL6). Particularly in VHL and MET, structural study of altered proteins revealed conformational alterations influencing protein activity.
Conclusion: By means of shared risk factors and molecular changes, urinary calculi and renal cancer cooccur and implied a common pathogenesis relationship including chronic inflammation, metabolic dysfunction and genetic abnormalities. These results highlighted the need of thorough clinical management and early genetic screening in reducing the risk and enhancing the outcomes for patients presenting with both diseases.

Citation:

Jin Li, Investigating the Co-occurrence of Urinary Calculi and Renal Carcinoma: A Comprehensive Analysis of Clinical and Molecular Associations Urinary calculi and renal cancer. The American Journal of Kidney Diseases 2024.