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Correspondence to Author: Mehmet Rami Helvaci^*, Guner Dede Kurt^**,Hulya Halici^***, Alper Sevinc^*,Celaletdin Camci^*,Abdulrazak Abyad^****,Lesley Pocock^*****. 

1. Specialist of Internal Medicine, MD, Turkey.
2. Specialist of Family Medicine, MD, Turkey.
3. Manager of Writing and Statistics, Turkey.
4. Middle-East Academy for Medicine of Aging, MD, Lebanon
5. Medi-WORLD International, Australia

DOI: 10.52338/taoim.2024.4247

Abstract:

Background: Atherosclerosis may be the major underlying cause of aging and death.
Methods: All patients with sickle cell diseases (SCD) were included.
Results: We studied 222 males and 212 females with similar ages (30.8 vs 30.3 years, p>0.05, respectively). Smoking (23.8% vs 6.1%, p<0.001), alcohol (4.9% vs 0.4%, p<0.001), transfused red blood cells (RBC) in their lives (48.1 vs 28.5 units, p=0.000), disseminated teeth losses (5.4% vs 1.4%, p<0.001), ileus (7.2% vs 1.4%, p<0.001), chronic renal disease (CRD) (9.9% vs 6.1%, p<0.05), coronary heart disease (18.0% vs 13.2%, p<0.05), cirrhosis (8.1% vs 1.8%, p<0.001), chronic obstructive pulmonary disease (25.2% vs 7.0%, p<0.001), leg ulcers (19.8% vs 7.0%, p<0.001), digital clubbing (14.8% vs 6.6%, p<0.001), and stroke (12.1% vs 7.5%, p<0.05) were all higher in males, significantly. .
Conclusion: As a prototype of systemic atherosclerosis, hardened RBC-induced capillary endothelial damage initiating at birth terminates with end-organ failures in much earlier ages in the SCD. Excess fat tissue may be much more important than smoking and alcohol for the development of atherosclerosis and end-organ insufficiencies in human being. The efficacy of metformin in loss of appetite is well known for several years. Since metformin is a safe, cheap, orally used, and effective drug for excess weight, it should be prescribed for the treatment of CRD even in normal weight individuals, since there are nearly 20 kg of excess fat tissue between the upper and lower borders of normal weight in adults.

Keywords:Sickle cell diseases, chronic renal disease, excess fat tissue, vascular endothelial inflammation, atherosclerosis, smoking, aging

Citation:

Dr. Mehmet Rami Helvaci, Metformin In The Treatment Of Chronic Renal Disease. The Annals of Internal Medicine 2024.