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Correspondence to Author: Dr.Brassai Attila 

George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania.

DOI: 10.52338/taoim.2025.4396

INTRODUCTION:

This review provides a comprehensive overview of what is known so far about the role of presynaptic receptors and transporters in the mode of action of some drugs used in medical practice. We will try to provide a synopsis of the pharmacological substances approved to be utilized with a mechanism of action on the presynaptic alpha-receptors as well as the presynaptic modulation of catecholamines via the uptake mechanism. Adrenergic effect on the alpha receptors is different according to the type of receptor: alpha-1 or alpha-2, respectively also by the fact if we exert effect on presynaptic or postsynaptic subtype of the receptor. Beside that we can induce agonistic or antagonistic effect [1] [2]. We examined the different types of alpha receptors and the active substances that can act on these receptors and modify the physiological response in order to achieve a clinico-therapeutic effect. Both alpha-receptor subtypes are G-protein linked, although alpha-1 causes an effect via Gq-protein, while alpha-2 performs his inhibitory effect via Gi-protein. Both mechanisms of action can be observed in the pre- and postsynaptic functioning of the receptors [3]. .

Citation:

Dr.Brassai Attila, Role Of Presynaptic Alfa Receptors. The Annals of Internal Medicine 2025.