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Correspondence to Author: Esperanza Avalos-Díaz, 

Department of Dermatology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, PR China.

Abstract:

A group of monozygotic male twin patients with autoimmune thyroiditis and vitiligo linked to the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes are the subject of our clinical, serologic, and immunogenetic investigations. Anti-melanocyte and anti-thyroid autoantibodies were observable in the patients. A critical analysis of the connection between MHC II molecules and the clinical signs of different autoimmune disorders manifested in a single patient, as the twin individuals described here have done.

Keywords : :  Autoimmunity, Autoimmune diseases, Vitiligo, Thyroiditis, Multiple autoimmunity, Epitope spreading

INTRODUCTION :
Numerous variables contribute to the polymorphic pathophysiology of multiple autoimmunity, a clinical and pathological problem that is poorly understood. There have been publications highlighting the genetic predisposition. connected to specific MHC alleles. For example, HLADQB1*04 has been connected with the expression of multiple bullous autoimmune disorders, including pemphigus and/ or pemphigoid linked to lupus, in the same patient [1,2]. Another illustration is the common correlation between thyroid disorders and vitiligo, as well as with Addison’s illness, atrophic gastritis, pernicious anemia, and other autoimmune pathologies 3–7. The aforementioned conditions typically show a mixed pattern of autoantibodies that are either nonorganic or specific to certain organs
We present clinical, serological, and immunogenetic investigations of two monozygotic twins in our work, who were mostly examined and treated for thyroid autoimmune illness.

Citation:

Esperanza Avalos-Díaz. Monozygotic twins: distribution of epitopes and multiple autoimmune. The Journal of Autoimmunity 2024.