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Correspondence to Author: Ivet Etchgaray-Morales, 

Department of Rheumatology, Medicine School, Meritorious Autonomous University of Puebla, Mexico.

Abstract:

A gram-negative bacteria called Helicobacter pylori, or H. pylori, attaches itself to the stomach mucosa and causes symptoms similar to gastritis. Due to the immunological interplay of cellular and humoral responses, chronic H. pylori infection can cause autoimmune disorders in persons with a hereditary susceptibility. A common infection is trigger for rheumatoid arthritis (RA), Sjogren syndrome (SS), and systemic lupus erythematosus (SLE), while it’s unclear if H. pylori causes these conditions. As a result, we discussed the therapeutic significance of this relationship.

Keywords : :  Helicobacter pylori, Systemic lupus erythematosus,Rheumatoid arthritis, Sj¨ogren, Syndrome, Infection

INTRODUCTION :
The spiral-shaped, gram-negative bacteria Helicobacter pylori, or H.pylori, is able to adjust to the acidic environment of the human stomach mucosa. At now, around 4.4 billion people worldwide carry the virus, with varying countryspecific prevalence rates ranging from 18.9% to 87.7% [1]. H. pylori colonization of the stomach mucosa is linked to mucosa-associated lymphoid tissue (MALT) gastric lymphoma, peptic ulceration, chronic active gastritis, and chronic atrophic gastritis [2,3]. A number of systemic illnesses, such as iron deficiency anemia [4], vitamin B12 insufficiency [5], non-alcoholic fatty liver disease [6], subclinical coronary atherosclerosis [7], insulin resistance, and metabolic syndrome [8], have been linked in recent research to H. pylori infection. Numerous researches have reported a connection between autoimmune diseases and H. pylori infection [9]. H. Patients with autoimmune illnesses should be concerned about pylori infections for a number of reasons. Firstly, reduced immune competence associated with autoimmune disorders is a result of disease symptoms or medication therapy; as a result, the likelihood of contracting H. pylori infection rises [10]. Second, non-steroidal anti-inflammatory drug (NSAID) side effects have the potential to inflict more harm [11]. Third, immune suppression raises the possibility of neoplasms, such as stomach cancer [12].

Citation:

Ivet Etchgaray-Morales. The autoimmune disorders systemic lupus erythematosus, rheumatoid arthritis, and Sjogren syndrome are linked to Helicobacter pylori. The Journal of Autoimmunity 2024.