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Correspondence to Author: Lilit Darbinyan, Uaren Simonyan, Karisa Manukyan, Vaghinak Sarkisian, Lusya Hovhannisyan, Lilia Hambardzumyan. 

University of Kansas Cancer Center, Kansas City, KS.

Abstract:

In South Africa, the herb Sutherlandia frutescens (SF) has long been used to treat a variety of illnesses, including neurological diseases. The loss of dopaminergic neurons in the substantia nigra is the hallmark of Parkinson’s disease (PD), a progressive neurodegenerative illness that causes motor symptoms. Both in vitro and in vivo investigations have connected the pesticide rotenone to symptoms similar to Parkinson’s disease. However, there hasn’t been much research done on how SF specifically affects PD symptoms. This study used an open-field test to evaluate motor behavior and in vivo electrical recordings from the hippocampus to examine the possible neuroprotective effects of SF against rotenone-induced Parkinson’s disease.Rats were split up into three groups: one that received sunflower oil as a control, one that received rotenone treatment, and one that received SF extract that was hydroponically cultivated. Motor behavior was assessed using an open-field test. Rats given SF showed noticeably more motor activity than rats given either sunflower oil or rotenone, indicating that SF has an activating effect on motor behavior. The rotenone group, on the other hand, showed decreased levels of activity and exploratory behavior, underscoring the drug’s inhibitory effect on motor function. According to these results, SF may provide neuroprotective benefits against rotenone-induced PDlike symptoms by modulating hippocampus neuronal activity. In an arotenone-induced Parkinson’s disease model, SF, a plant with traditional medicinal uses, exhibits promise in modifying motor behavior and hippocampus neuronal activity

Keywords:Sutherlandia Frutescen, Open-Field Testing, Parkinson’s Disease, In Vivo Electrophysiology.

Citation:

Dr.Lilit Darbinyan, Assessment Of Sutherlandia Frutescens Neuroprotective Potential In A Rotenone-Induced Parkinsons Disease Rat Model. Advances in Behavioral Neuroscience 2025.