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Correspondence to Author: Jerie D. Olver, 

Introduction: Although systemic anticoagulation and its reversal carry known dangers, they are sometimes considered required. However, systemic hemostasis changes are frequently unnecessary when local therapy can make the necessary alterations, especially in plastic surgery patients. An overview of the clinical uses of topical anticoagulant and procoagulant therapy in cosmetic and reconstructive surgery was the goal of this review. Hemostats are frequently used to stop bleeding, local anticoagulants like heparin can increase flap survival, and local tranexamic acid (TXA) has demonstrated promise in attaining hemostasis under diverse situations, albeit this research is still in its infancy. Drug delivery is the primary obstacle to the development of local treatment.

Keywords:coagulation; anti-coagulation; drug delivery; local therapy; flaps; plastic surgery.

Citation:

Jerie D. Olver. A Review Of The Literature On The Evidence And Clinical Uses Of Local Pro- And Anti-Coagulation Therapy In Plastic Surgery Patients. Advances in Plastic Surgery 2025.