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Correspondence to Author: Variu Ardeleanu, 

Introduction: A diverse category of T-cell (CTCL) and B-cell lymphomas (CBCL), primary cutaneous lymphomas form in the skin and are diagnosed without extracutaneous illness symptoms. Its indolent clinical behavior and unclear malignant potential led to the term “primary small/medium CD4+ T-cell lymphoma” being altered to “primary small/medium cutaneous CD4+ lymphoproliferative disorder.” A uncommon example of small to medium CD4+ T-cell primary cutaneous lymphoma is presented in this research. A 37-year-old patient came in with a frontal tumor that had developed about 8 to 9 months prior. The tumor was round in shape, about 6–7 mm high, pink in color, firm in substance, painless to the touch, and had a diameter of around 8–9 mm. It was also well defined macroscopically. The tumor was surgically removed deep to the level of the frontal muscle fascia, with an 8 mm margin of safety. The histological analysis confirmed the diagnosis of cutaneous lymphoproliferation, which is mostly made up of scattered medium-large lymphocytes, with a nodular distribution in the reticular dermis and extension around the follicular epithelia and sweat glands. More immunohistochemistry analysis was asked for. The diagnosis of “primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder” was validated by immunohistochemical analysis. Clinical dermatological controls were used to monitor the patients at 3, 6, and 12 months. A cranio-cerebral MRI was done a year later. An yearly dermatological check, blood count, lung X-ray, and craniocerebral MRI were advised for the next five years.

Keywords:cutaneous lymphoma; immunohistochemistry; dermoscopy; cutaneous tumor.

Citation:

Variu Ardeleanu. >Surgical, Dermatological, And Morphological Factors In The Diagnosis And Management Of Primary Cd4+ Cutaneous Lymphoproliferative Tumors. Advances in Plastic Surgery 2025.