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Correspondence to Author: Farhad Salehzadeh, 

Farhad Salehzadeh Professor of Pediatric Rheumatology, Pediatric Department, Bouali Children`s Hospital, Ardabil University of Medical Sciences (ARUMS), Nationality: Ardabil, Iran.

Abstract:

Background
About 30% of epilepsies are refractory to anti epileptic drugs, many studies have suggested that innate immune system and inflammatory processes can have a potential role in pathophysiology of refractory epilepsy (RE). MEFV gene plays a major role in auto-inflammatory disorders and innate immune system. The aim of this study is to determine the possible role of MEFV gene mutations in children with refractory epilepsy.
Method and Materials
The peripheral blood of 15 patients who had RE were collected and the samples screened for the 12 common pathogenic variants alleles of MEFV gene using ARMS-PCR and Sanger Sequencing method, and compared with the results of healthy control group.
Results
The patients’ group included 7 girls (46.7%) and 8 boys (53.3%). The mean age of patients was 9.33 years and at the onset of seizures was 1.66 years. None of the patients showed these common pathogenic variants alleles.
Conclusion
This study showed despite the possible and potential role of auto-inflammatory processes and innate immune system involvement in RE, there is no association between activation of innate immune pathway by MEFV gene variants alleles as an auto-inflammatory immunogenic factor.

Citation:

Farhad Salehzadeh. Innate Immune role in Refractory Epilepsy as an auto inflammatory immunogenic factor through MEFV gene Variant Alleles. Clinics of Neurology 2024.