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Correspondence to Author:  Md.Jahangir Alam^1*,Most.Nur-E-Taj Mokarrama Mukti²;Bilkis sultana¹,Md. Anisuzzaman khan¹,Arnab Kumar Sarker¹, & Sunil Chandra Mallik³ 

1. Most. Nur-E-Taj Mokarrama Mukti, Department of Zoology, University of Rajshahi, Bangladesh. E-mail: muktialam156@gmail.com
2. Bilkis sultana, Junior Experimental officer, General laboratory. BRDEM General Hospital, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Shabagh, Dhaka-1000. E –mail: bilkis78.bs@gmail.com
3. Md. Anisuzzaman khan, Experimental officer, General laboratory. BRDEM General Hospital, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Shahbagh, Dhaka-1000, Bangladesh. E-mail: khanmd.zaman1968@gmail.com
4. Arnab Kumar Sarker, Senior Research officer, department of immunology. BRDEM General Hospital, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Shahbagh, Dhaka-1000, Bangladesh. E-mail: sarkerarnab21f@gmail.com
5. Sunil Chandra Mallik, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh. E-mail: such.mallik@gmail.com

DOI: 10.52338/job.2024.4128

Abstract:

The prevalence of diabetes is rising in Bangladesh, posing significant health challenges. This cross-sectional study conducted at BIRDEM General Hospital in Dhaka, Bangladesh, involved 1,020 subjects, including 752 with type-2 diabetes and 268 non-diabetic controls, aged 23 to 87 years. The study aimed to compare serum levels of magnesium, electrolytes (sodium, potassium, chloride, total carbon dioxide), calcium, amylase, and lipase between diabetic and non-diabetic subjects, and to explore correlations among these parameters. Diabetic subjects exhibited significantly higher mean levels of fasting blood sugar (P < 0.01), urea (P < 0.01), creatinine (P < 0.01), amylase (P < 0.01), and lipase (P < 0.01) compared to non-diabetic subjects. Conversely, sodium (P < 0.01), potassium (P < 0.01), chloride (P < 0.01), total carbon dioxide (P < 0.05), calcium (P < 0.01), magnesium (P < 0.01), and inorganic phosphate (P < 0.01) concentrations were significantly lower in diabetic subjects. Fasting blood sugar showed negative correlations with urea (P < 0.01) and inorganic phosphate (P < 0.02) in diabetic subjects. Multivariate analysis adjusted for age and sex revealed significant associations of fasting blood sugar with all parameters except urea, total carbon dioxide, and potassium. These findings underscore the importance of monitoring serum magnesium in type-2 diabetes and considering magnesium supplementation where necessary.

Citation:

Dr. Jahangir Alam. A Cross-sectional Study of Serum electrolytes, Calcium, and Magnesium Levels in Diabetic and Non-diabetic Subjects in Dhaka City, Bangladesh. Journal of Biochemistry 2024.