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Correspondence to Author:  Md.Jahangir Alam^1*,Most.Nur-E-Taj Mokarrama Mukti²;Bilkis sultana¹,Md. Anisuzzaman khan¹,Arnab Kumar Sarker¹, & Sunil Chandra Mallik³ 

1. Most. Nur-E-Taj Mokarrama Mukti, Department of Zoology, University of Rajshahi, Bangladesh. E-mail: muktialam156@gmail.com
2. Bilkis sultana, Junior Experimental officer, General laboratory. BRDEM General Hospital, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Shabagh, Dhaka-1000. E –mail: bilkis78.bs@gmail.com
3. Md. Anisuzzaman khan, Experimental officer, General laboratory. BRDEM General Hospital, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Shahbagh, Dhaka-1000, Bangladesh. E-mail: khanmd.zaman1968@gmail.com
4. Arnab Kumar Sarker, Senior Research officer, department of immunology. BRDEM General Hospital, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Shahbagh, Dhaka-1000, Bangladesh. E-mail: sarkerarnab21f@gmail.com
5. Sunil Chandra Mallik, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh. E-mail: such.mallik@gmail.com

DOI: 10.52338/job.2024.4399

Abstract:

Hypertension is a leading risk factor for complications in diabetes mellitus patients, and hyperlipidemia is frequently observed among individuals with diabetes. This study compared the lipid profiles and cardiac enzyme levels in diabetic and non-diabetic individuals in Bangladesh, focusing on fasting blood glucose, cardiac enzymes, and lipid profiles. Serum samples were analyzed to measure total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), and triglycerides (TG). Cardiac biomarkers; creatine phosphokinase (CPK), creatine kinase-MB (CK-MB), and lactate dehydrogenase (LDH) were also assessed. A total of 620 diabetic and 520 non-diabetic participants aged 30-60 years were included to examine differences in lipid profiles and cardiac enzyme levels. This study observed mean values of TC (p=0.003), TG (p=0.001), BMI (p0.001), LDL-C (p=0.036), CKMB (p0.001) and LDH (p0.001) were significantly higher in diabetic patients than in the nondiabetic patients. However no significant difference was observed in HDL-C (p=0.168) and CPK (p=0.090) levels between diabetic and non-diabetic groups.

Citation:

Dr. Jahangir Alam. Evaluation of Serum Lipid and Cardiac Enzyme Status in Diabetic and Non-Diabetic Adults in Dhaka, Bangladesh. Journal of Biochemistry 2024.