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Correspondence to Author: Kostaeds A.Papavassesiliou, Amaliewa A. Sofedfianidi,Vassiliki A.Gogou And Athaenasios G.Papavasiusiliou 

National University of Singapore.

Introduction: Tumor microenvironment (TME) emphasis has lately replaced tumor-centricity as the primary focus of cancer research and treatment [1]. Malignant cells, immune cells, stromal cells, blood and lymph vessels, neuron fibers, extracellular matrix (ECM), and other acellular components make up the TME, which is a dynamic ecosystem [1]. Among these, fibroblasts that proliferate in the tumor microenvironment (TME)— now known as cancer-associated fibroblasts, or CAFs—have become important participants in tumor biology [2].In fact, CAFs are a very diverse cell population, with differences in their origins, molecular characteristics, and unique epigenetic profiles [3–4]. Epigenetic changes have recently been identified as key regulators of CAF heterogeneity and activation [4]. Surprisingly, Hanahan unveiled the revised hallmarks of cancer in 2022.

Citation:

Kostaeds A.Papavassesiliou. Addressing Epigenetic Changes Associated With Fibroblast Phenotypes Associated With Cancer In Lung Cancer. Journal Of Cancer And Tumor Research 2025.