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Correspondence to Author: JLakmali Perera , 

School of Dentistry & Oral Health, Gold Coast Campus, Griffith University, Australia (Alumni)

Abstract:

The role of infection associated inflammation in oral cancer gained much attention and at least 15 % of oral cancer is suspected to be associated with chronic inflammation [1-3]. Poor oral hygiene has emerged as an independent risk factor for Oral Squamous Cell Carcinoma (OSCC) substantiated by evidence of recent past research [4-6]. Poor oral hygiene may cause periodontitis [7]. In several studies, periodontitis reported to be associated with increased risk of OSCC [8-12]. Periodontitis is an inflammatory disease of the periodontium caused by combined action of polymicrobial communities [13]. Carcinogenic attributes of two periodontopathogenic bacteria Fusobacterium nucleatum [3] and Porphyromonas gingivalis [3] have been revealed by in vivo and in vitro studies, especially these two major periodonto pathogens reported to be promoted tumour progression [3].

Keywords:Polymicrobial Synergy, Dysbiosis, Periodonto Pathogens, Oral Squamous Cell, Carcinoma Tumour, Micro Environment

Citation:

JLakmali Perera. Possibility of Polymicrobial Synergy and Dysbiosis of Periodonto Pathogens in the Oral Squamous Cell Carcinoma Tumour Micro Environment. Journal of Dentistry and Oral Research 2024.