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Correspondence to Author:  Dr. Arturo Solis Herrera, 

Human Photosynthesis© Research Centre. Aguascalientes 2000, México

Abstract: Carbonic anhydrase (CA) is a zinc metalloenzyme widely distributed throughout the tissues of the body. In the kidney, this enzyme is thought to play a pivotal role in urinary acidification and bicarbonate reabsorption. Two distinct isozymes of carbonic anhydrase have now been identified in the mammalian kidney. A soluble cytoplasmic form, similar if not identical to human erythrocyte carbonic anhydrase C, accounts for the bulk of the renal carbonic anhydrase activity. In addition, a membrane-bound form constituting only about 2--5% of the renal activity has been found in the brush border and basolateral fractions of kidney homogenates. The activity of carbonic anhydrase enzyme is incessantly, which means a high energy expenditure, but ATP is not the source of energy of this enzyme (CA). The kidney generates 180 liters of filtrate a day. The process is also known as hydrostatic filtration due to the wrong belief that 180 liters of filtrate a day as result of the hydrostatic pressure exerted, by the left ventricle; on the capillary walls of the kidney. However, the cardiac pressure required to impel the blood stream at adequate level is way beyond 120 mm Hg output force that left ventricle has.

Citation:

Dr. Arturo Solis Herrera. Carbonic anhydrase, water dissociation and physiology of Kidney The Journal of Nephrology 2024.