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A single center’s experience with atypical presentation of Merkel cell carcinoma positive for polyomavirus DNA detection.

Correspondence to Author:  Trancesco Bovino, 

Dipartimento di Scienze Anestesiologiche, Chirurgiche e dell’Emergenza, Seconda Università degli studi di Napoli, Italia.


Merkel cell malignant neoplastic disease (MCC) could be a rare malignant neoplasm of the skin with tendency to speedy native progression and frequent unfold to regional humor nodes. during this paper 10dency to|we tend to} retrospectively describe the atypical presentation of five cases of Merkel cell malignant neoplastic disease determined in our surgical department within the last ten years. Four patients had cheek localization while one patient had primary nodal presentation. Since integration of Merkel cell polyomavirus (MCPyV) deoxyribonucleic acid into the neoplasm order is often recorded during this form of cancer, we tend to analyzed formalin-fixed paraffin embedded MCC tissue samples from our 5 patients for the presence of MCPyV deoxyribonucleic acid by means that of enzyme chain reaction (PCR). MCPyV deoxyribonucleic acid was gift all told 5 carcinomas. All patients were treated with wide surgical excision of the neoplasm and watcher node diagnostic assay. One patient had stage I illness, 3 patients had stage II illness, and one patient had stage III illness. Adjuvant actinotherapy was administered all told cases for native management. therapy was administered to the patient with primary nodal presentation and in stage III illness. Median time of follow-up was eighty four months. None of the patients relapsed. Despite the low range of patients examined, our expertise suggests that surgery could be a necessary step whereas implementation of adjuvant medical aid, actinotherapy and therapy depends on individual risk assessment. Treatment outcome was excellent, most likely thanks to early detection of MCC.

Keywords :
Merkel cell carcinoma; polyomavirus; DNA detection; chemotherapy.


Trancesco Bovino. A single center’s experience with atypical presentation of Merkel cell carcinoma positive for polyomavirus DNA detection. World Journal of Clinical Cancer Research 2024.

Journal Info

  • Journal Name: World Journal of Clinical Cancer Research
  • Impact Factor: 2.0
  • ISSN: 2831-3275
  • DOI: 10.52338/Wjccr
  • Short Name: WJCCR
  • Acceptance rate: 55%
  • Volume: 6 (2024)
  • Submission to acceptance: 25 days
  • Acceptance to publication: 10 days


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