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Correspondence to Author: Pmal Alharbi , orika Womack, ferenYarar-Fisher. 

University of California, Irvine, Health, Orange, CA.

Abstract:

Introduction: In this case study, a patient with acute spinal cord injury (SCI) and lower motor neuron lesions (LMNLs) has their muscle glucose signaling, fiber type distribution, and metabolic function evaluated in relation to a novel combined neuromuscular electrical stimulation (CombNMES) regimen. Report on the Case: The quadriceps were the focus of a ten-session Comb-NMES intervention for a 32-year-old individual with complete T9 SCI. To assess changes in muscle fiber types, important metabolic proteins, fasting insulin, glucose, and lipid profiles, muscle biopsies and blood samples were examined both before and after the intervention.Fasting insulin and glucose were reduced by 74.7% and 28.2%, respectively, as a result of the intervention. Improved glucose metabolism was indicated by muscle analysis, which revealed notable increases in CaMK II, Hexokinase II, and IRS-1.Conclusions: In a patient with acute SCI and LMNLs, Comb-NMES training significantly enhanced muscle glucose metabolism and metabolic regulation. Enhanced insulin sensitivity and glucose consumption were indicated by upregulated metabolic proteins, which implies that Comb-NMESisapromisingintervention for enhancing muscle and metabolic health in SCI.

Keywords: Spinal Cord Damage, Lesion Of A Lower Motor Neuron, Coupled Neuromuscular Electrical Stimulation, Muscle Atrophy, Muscle Glucose Uptake.

Citation:

Dr. Pmal Alharbi, Effect Of Combined Neuromuscular Electrical Stimulation (Comb-Nmes) On Muscle Myofiber Distribution And Glucose Signaling In A Patient With Lower Motor Neuron Lesion And Acute Spinal Cord Injury. Advances in Behavioral Neuroscience 2025.