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Correspondence to Author: Xinli Zhou^a, Huihui Chen^b, Jiawei Wang^b, Miao Wu^b,Ruiling Hu^b, Junpeng Yang^b, Tinghui Qiang^a, Huan Mou^a, Xingguo Du^a, Fei Gao^a, Zhongshang Guo,^a* 

a. Department of Osteoarticular Surgery Department, Hanzhong Central Hospital, Hanzhong 723000, Shaanxi, China.
b. Shaanxi Key Laboratory of Catalysis, School of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong 723000, Shaanxi, China.

DOI: 10.52338/joes.2024.4052

Abstract:

In recent years, the widespread use of antibiotics has led to the emergence of numerous drug-resistant bacteria, posing a severe threat to both human health and the economy. As a result, it is imperative to develop efficient antibacterial agents that do not induce drug resistance. This study employed layer-by-layer assembly technology to prepare ZnFe2O4@ZnS/Cu2S nanocomposites, which were systematically characterized using transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, energy dispersive spectroscopy, and Fouriertransform infrared spectroscopy. Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and drug-resistant Salmonella (T-Salmonella) were utilized as test bacteria to investigate the antibacterial effectiveness and mechanism of ZnFe2O4@ZnS/Cu2S. The findings demonstrated that, the MIC of the ZnFe2O4@ZnS/Cu2S against E. coli, S. aureus and T-Salmonella were 50, 60 and 80 μg/mL, respectively; At a material concentration of 200 μg/mL and a reaction time of 80 min, ZnFe2O4@ZnS/Cu2S demonstrated a bacteriostatic rate of 99.99% against the three tested bacteria. The nano-composite can disrupt cell walls and plasma membranesand effectively and resulting in bacterial rupture and demise. Furthermore, the nanocomposite displayed strong biocompatibility which, together with its superior antibacterial effects, indicate significant potential for its application in medical materials and other areas of research.

Citation:

Shaobo Guo. Synthesis and antibacterial properties of core-shell nano-ZnFe2O4@ZnS/Cu2S composites. Journal of Environmental And Sciences 2024.