Author Login

Correspondence to Author: Giuseppina Garbelli¹, Federico Maffezzoni², Serena Miglio², Patrizia Giordano³, Stefano Agostini⁴. 

1.Vigoni della Somaglia Foundation, Somaglia (LO), Italy
2.Clinical Psychology, Oberdan Outpatient Clinic, Brescia (BS), Italy
3.Scientific Researcher, Lodi (LO), Italy
4.MèDISIN S.r.l., Lissone (MB), Italy

DOI: 10.52338/jonafsr.2025.5214

Abstract:

The general population commonly utilizes nutritional supplementation with one or more water-soluble vitamins to reduce perceived stress and fatigue, improve physical and mental performance, as well as sleep quality. However, to date, no published studies have evaluated the daily use of a nutraceutical formulation combining inositol with high doses of all water-soluble vitamins, aimed at reducing emotional distress, physical and mental fatigue, and perceived stress, while improving psychological well-being, cognitive function, and sleep quality in healthy individuals aged 18 to 65 years. This study provides a preliminary contribution to addressing this gap. In this prospective, comparative, parallel-group study, the effects of daily intake of a nutraceutical tablet containing inositol and high doses of all water-soluble vitamins called Vidrosol•50® (V50) were evaluated on 139 healthy male and female subjects presenting with emotional distress, symptoms of mental and physical tiredness and listlessness, a feeling of general debilitation, and sleep disturbances such as excessive sleepiness and/or difficulty awakening. The enrolled subjects were divided into two groups: one group of 71 subjects was treated with the nutraceutical and compared to a second group of 68 subjects with very similar demographic and medical history characteristics presenting the same conditions who, during the same period, did not take any nutraceutical or drug for the treatment of these conditions. All subjects involved in the study completed the General Health Questionnaire (GHQ-12), the Fatigue Assessment Scale (FAS), the Multidimensional Inventory of Subjective Cognitive Impairment (MISCI), the Perceived Stress Scale (PSS), and a Sleep Quality Scale (SQS) at baseline (T0), and at follow-up assessments conducted after 7 days (T1) and 30 days (T2). The use of V50 resulted in statistically significant improvements in the total scores of all questionnaires administered already at T1. These improvements were further accentuated at T2. In the untreated subjects, no significant variations in the total questionnaires scores were observed over the same time frame. The tested nutraceutical was confirmed to be safe and well tolerated: no subject discontinued the intake of V50 due to adverse effects attributable to the nutraceutical. The study results provide evidence that healthy male and female subjects can benefit from increased intake of inositol and all water-soluble vitamins through the daily administration of a nutraceutical containing inositol and high doses of all water-soluble vitamins. Specifically, this supplementation led to significant improvements, already evident by day 7, in validated assessments of emotional distress and psychological well-being, physical and mental fatigue, cognitive functions, perceived stress, and sleep quality.

Citation:

Stefano Agostini, Inositol And High-Dose Water-Soluble Vitamins Supplementation To Improve Psychological WellBeing, Cognitive Function, Perceived Stress, Physical Fatigue, And Sleep Quality. Journal of Nutrition and Food Science Research 2025.