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How to Respond to Reviewer Comments (With Example Replies)

DE By Directive Editorial Team, Directive Publications ·17 Jul 2026 ·7 min read
How to Respond to Reviewer Comments (With Example Replies)

In short: A "revise and resubmit" decision is good news — the editor wants to publish an improved version of your work. Respond with a clear, respectful, point-by-point letter that addresses every comment and shows exactly what you changed.

First, the right mindset

Reviewer comments can feel personal, but they are not. Peer review exists to strengthen your work, and a request for revisions means the editor sees potential in it. Read the comments once, set them aside for a day, then return ready to improve the manuscript.

Structure your response

Prepare a separate response-to-reviewers document. For each comment:

  1. Quote the comment exactly.
  2. Reply directly beneath it, describing what you did.
  3. Point to the change — note the section, page or line where the reviewer can see it.

Address every comment, even minor ones. Number them to match the reviewers' numbering, and consider marking changes in the manuscript so they are easy to find.

How to reply to different kinds of comment

When you agree

Comment: The sample size justification is missing. Response: We agree. We have added a sample-size calculation to the Methods (page 5, paragraph 2) and now report the assumptions used.

When you partly agree

Response: We agree that the limitation should be clearer. We have expanded the Discussion (page 11) to address this. We were unable to collect the additional data the reviewer suggests within the study period, and we now note this explicitly as a direction for future work.

When you respectfully disagree

Response: We appreciate this point. We have retained the original analysis because [clear reason with evidence or citation]. We have, however, added a sentence acknowledging the alternative interpretation the reviewer raises (page 9).

Disagreement is legitimate — but it must be polite, reasoned and evidence-based. Never dismiss a reviewer.

Handling contradictory reviewers

If reviewers disagree with each other, acknowledge both, explain the conflict, and describe the path you chose and why. You may also ask the handling editor for guidance.

Practical tips

  • Be courteous and thank the reviewers — they gave their time for free.
  • Be thorough: a complete response is more persuasive than a defensive one.
  • Meet the deadline, or ask for an extension before it passes.
  • Keep a professional tone throughout; the editor reads your letter too.

Key takeaways

  • A revision decision is an opportunity, not a rejection.
  • Respond point by point: quote, reply, and show where you changed the text.
  • Address every comment; disagree only with evidence and courtesy.
  • Be thorough, polite and on time.

Frequently Asked Questions

Does "major revisions" mean my paper will be rejected?
No. A revision decision means the editor sees potential in your work and wants to see it improved. A careful, complete response gives you a strong chance of acceptance.
Do I have to make every change a reviewer asks for?
You should address every comment, but you do not have to agree with all of them. Where you disagree, explain your reasoning politely and support it with evidence. The editor makes the final decision.
What if two reviewers contradict each other?
Acknowledge both comments, explain the conflict, and describe the approach you took and why. You can also ask the editor for guidance. Reviewers disagreeing is normal.
How should I format my response?
Write a separate response document that quotes each comment and gives your reply directly beneath it, noting where in the manuscript you made the change. A clear, point-by-point letter is much easier for editors and reviewers to follow.
How long do I have to revise?
Journals usually set a deadline (often a few weeks to a couple of months). If you need more time, ask the editor before the deadline — this is normal and usually granted.
DE
Directive Editorial Team
Directive Publications

The editorial team at Directive Publications — an international open-access publisher of peer-reviewed medical and scientific journals.

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