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Correspondence to Author:  Lijun Yin¹, Guoliang Xie²,Ahmad Alhaskawi³,Yanzhao Dong³,Zewei Wang⁴, Chengjun Yao⁴, OlgaAlenikova⁵, Sahar Ahmed Abdalbary⁶, ZhenfengLiu⁷, Weihua He¹, Hui Lu³,^* 

1. Department of Obstetrics and Gynecology, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China,310003
2. Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China,310003
3. Department of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China,310003 4. Zhejiang University School of Medicine, #866 Yuhangtang Road, Hangzhou, Zhejiang Province, P. R. China, 3100058
5. Department of Neurology, Republican Research and Clinical Center of Neurology and Neurosurgery, Minsk, Belarus.
6. Department of Orthopedic Physical Therapy, Faculty of Physical Therapy, Nahda University, Beni Suef, Egypt.
7. Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China, 3100058.

DOI: 10.52338/job.2024.4114

Abstract:

COVID-19 is currently one of the most widespread infectious diseases globally. The goal of this research is to present a new understanding regarding the connection between SARSCoV-2 and ovarian activity among women of childbearing age. In this observational study, clinical information from 218 women who were infected with SARS-CoV-2 was analyzed retrospectively. The relationship between the severity of the disease and sex hormone levels is analyzed and compared. E2 and T levels showed a significant downward trend with the aggravation of COVID-19 disease, and the difference was significant (P=0.000286, P=0.009). FSH and LH were not significantly affected(P=0.184, P=0.129), although they appeared to decline with disease progression. There were no significant P-values for age, prolactin and progesterone, AMH levels, and FSH/LH in the three groups of patients, with P=0.096, P=0.341, P=0.12, P=0.542, P=0.636, respectively. The significantly reduced E2 and T levels in the severely infected group suggest that SARS-CoV-2 may affect glands and related hormones directly or indirectly. The AMH showed no significant change, indicating that comprehensive ovarian reserve function was not affected in the short term, but longterm follow-up observation is required.

Citation:

Fatemeh Moradian. In silico study of lactoferrin as an anticancer, anti-viral, and anti-bacterial bioactive compound and disease diagnostic marker. Journal of Biochemistry 2024.