Correspondence to Author:  Bo Zhenga, Peng Yin^a, Xiangling Liao^a, Yanhong Pei^b*. 

^aDepartment of Stomatology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
^bDepartment of Bone Tumor, Peking University People’s Hospital, Beijing, China.

DOI: 10.52338/immunology.2024.4260

Abstract:

Objective: In this study, we aimed to explore the reciprocal cause-and-effect relationship between temporomandibular disorders (TMDs) and rheumatoid arthritis (RA).
Materials and Methods: We perfomed a two-sample bidirectional Mendelian randomization (MR) analysis from genome-wide association studies. The primary analysis approach used was inverse variance weighting (IVW), with supplementary analyses using MR-Egger, weighted median method, simple mode, and weighted mode to assess the causal relationship between TMD and RA, with odds ratios (ORs) and 95% confidence intervals (CIs). Heterogeneity testing and assessment of multiple validity were performed using Cochran’s Q, MR-Egger, and MR-pleiotropy residual sum and outlier methods.
Results: The general results of the forward MR analysis indicated that TMD had a significant causal effect on RA (IVW: OR = 1.125, 95% CI = 1.013–1.249, P = .028). However, the reverse MR analysis results suggested that RA had a dramatic causal effect on TMD (IVW: OR = 1.074, 95% CI = 1.025–1.126, P = .003). Finally, the stability and reliability of the causal association between the above combinations were confirmed through sensitivity analyses and other tests.
Conclusion: Our results demonstrated a hereditary causative relationship between TMD and RA. The findings emphasize the need for clinicians to additionally consider patients with RA when consulting for TMD and give more attention to patients with TMD, especially those undergoing pain control.

Citation:

Yanhong Pei. Causal Relationship Between Temporomandibular Disorders And Rheumatoid Arthritis: A Bidirectional Mendelian Randomization Analysis. Journal of Immunology 2024.