Correspondence to Author: Yanhong Pei¹, Jiarui Liu^2,3,4, Wei Guo^1*. 

¹ Department of bone tumor, Peking University People’s Hospital, Beijing, China.
²Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing, China.
³ Neuroscience Research Institute, Peking University, Beijing, China.
⁴ Key Laboratory for Neuroscience of Ministry of Education, Peking University, Beijing, China.

DOI: 10.52338/immunology.2025.4322

Abstract:

Biomaterials possess electrical, optical, and magnetic properties, which make them promising candidates for targeted drug delivery. Moreover, their biocompatibility and low toxicity render them suitable for applications in tumor therapy. We conducted a bibliometric review to investigate trends in biomaterials for bone tumor therapy. Relevant studies published between 2013 and 2024 were identified using the Web of Science database. The Bibliometric R-package and CiteSpace software were used to quantitatively analyze the number of papers, countries, authors, institutions, sources, co-cited literature, and keywords. Papers were categorized according to the main research subject, and those cited at least 10 times annually were qualitatively analyzed. Over the last decade, the number of papers and mean annual citation rate increased. Most papers originated from the USA and China, and the institutions with the highest contributions were the University of California and Harvard University. Among authors, Zhang had the highest number of published articles and maximum citations according to the H-index. The International Journal of Radiation Oncology, Biology, Physics had the highest number of publications. Keyword analysis revealed a focus shift from cells, receptors, and gene therapy to immunological therapy, photothermal therapy, and drugs. Notably, recent research has mainly considered external and internal microenvironmental stimuliresponse strategies. This review offers a valuable basis for developing intelligent and versatile biomaterials for bone tumor therapy and regeneration in future investigations.

Keywords: bibliometric analysis, biomaterials, bone tumor, CiteSpace, therapy

Citation:

Dr.Yanhong Pei, Global Landscape Of Bone Tumor Therapy And Biomaterials: A Bibliometric And Citespace Analysis. Journal of Immunology 2025.