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Correspondence to Author: Nunzio Di Naro¹, Marta Meloni¹,Tolu Giovanni Antonio^1,2. 

1. Pathological Anatomy Operations Unit, “San Martino” Hospital, Oristano, Italy.
2. Director of Pathological Anatomy Operations Unit, “San Martino” Hospital, Oristano, Italy.

DOI: 10.52338/aou.2025.4548

Abstract:

We describe the clinical case of a older woman with a previous diagnosis of moderately and poorly differentiated and non-infiltrating bladder cancer (G2-G3) trated with Bacillus Calmette-Guerin (BCG) and with a subsequent histological diagnosis of nephrogenic adenoma.The material sent for histological examination, received in various fragments papillary-looking and fixed in 4% formalin, was sampled and included in paraffin. At the microscope in one of the fragments there was a cell proliferation with tubular architecture, consisting of monostratified cuboid cells with a large nucleus and scarce eosinophilic cytoplasm. These cells showed positivity for CK7 and PAX8, negativity for CK20 and focal positivity for GATA3, Ki67 showed a low proliferative index. The histopathological diagnosis was nephrogenic adenoma. The subsequent follow-up of the patient, who is still alive and in good health, was negative.The differential diagnosis is with urothelial papilloma, low-grade urothelial neoplasms, prostatic adenocarcinoma, urothelial carcinoma of uncertain histology and clear cell bladder carcinoma, although the latter is rare.
Finally, since recurrence is frequent, constant follow-up is required.
Keywords: Urinary Bladder[1] , Nephrogenic adenoma[2], Nephrogenic Metaplasia[3] , Urinary Bladder neoplasms[4], Urologic Diseases[5], Urothelial Carcinoma[6].

Citation:

Dr.Marta Meloni, Nephrogenic Adenoma Of The Bladder. Annals of Urology 2025.