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Correspondence to Author: Arnab KC^1*, Wadud Chowdhury², Suman KS³,Akteruzzaman⁴, Anjuman Begum⁵, Barua Sushanta⁶. 

1. Dr.Arnab Kumar Chowdhury, MBBS, MD, Medical officer Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh. Email : Arnabchowdhury2388@gmail.com
2. Prof. Dr, Md. Wadud Chowdhury, MBBS, MD, Professor &Head of Cardiology, Dhaka , Medical College, Dhaka ,Bangladesh. Email : drwadud@hotmail.com
3. Dr.Suman Kumar Saha, MBBS, MD, Assistant Professor of Cardiology, Dhaka Medical College, Dhaka ,Bangladesh. Email : drsumankumarsaha74@gmail.com
4. Dr .Md. Akteruzzaman, MBBS, MD, Junior Consultant Cardiology, Sathkira Medical College Hospital, Sathkira, Bangladesh, Email : mdakteruzzamansb27@gmail.com
5. Dr.Anjuman Ara Begum, MBBS, MD, Junior Consultant, Mugda Medical College hospital, Dhaka, Bangladesh. Email : jollysafed@gmail.com
6. Dr. Sushanta Barua, MBBS, MD, Assistant Registrar Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh. Email : sbarua330@gmail.com

DOI: 10.52338/jocd.2024.4190

ABSTRACT

Background The relationship between serum uric acid and chronic stable angina remains contentious. While its association with cardiovascular risk is debated, this study aimed to investigate the correlation between serum uric acid levels and the angiographic severity of coronary artery disease in patients with chronic stable angina.
Methods A cross-sectional analytical study was conducted on 158 patients presenting with chronic stable angina at Dhaka Medical College Hospital from January to December 2022. Hyperuricemia was defined as serum uric acid levels ≥ 6.5 mg/ dl. The severity of coronary artery disease was assessed using the Gensini score and the vessel score on coronary angiogram.
Results Hyperuricemic patients (n=72) had significantly higher conventional risk factors (hypertension, diabetes, dyslipidemia) and lipid profile abnormalities compared to the normouricemic group (n=86). Notably, hyperuricemic patients were more likely to have a vessel score of 3 (severe coronary artery disease) and had significantly higher Gensini scores, indicating greater disease severity. A strong positive correlation was observed between serum uric acid levels and both Gensini score and vessel score.
Conclusions This study demonstrates a significant positive association between serum uric acid levels and the severity of coronary artery disease in patients with chronic stable angina. Early diagnosis and management of hyperuricemia may be crucial in reducing adverse clinical outcomes and improving the quality of life for these patients.

Citation:

Sushanta Barua. Association Of Hyperuricemia With Angiographic Severity Of Coronary Artery Disease In Chronic Stable Angina Patients. Journal of Cardiovascular Diseases 2022.