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Correspondence to Author: Than Dep,Tam Tai Thanh Tra,Chun Kha Hang,Sam Min Tai. 

Faculty of Health Sciences, Autonomous University of Baja ,Vietnam.

Abstract:

For transplants to be effective and kidney donation practices to be protected, a precise evaluation of the glomerular filtration rate (GFR) in potential living kidney donors (PLKDs) is necessary. Many people consider scintigraphy-measured GFR (mGFR) to be the clinical reference standard. A number of estimated GFR (eGFR) formulas have been created, including the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Cockcroft–Gault (CG), and the Modification of Diet in Renal Disease (MDRD); however, none of them have been specifically validated for Vietnamese PLKDs.The purpose of this study was to compare the accuracy of eGFR formulas to mGFR in PLKDs.Methods:From January 2014 to December 2020, 189 PLKDs at Cho Ray Hospital in Vietnam were examined in this convenient retrospective analysis. Several formulas were used to determine the eGFR, and 99mTechnetiumdiethylenetriaminepentaacetic acid was used to compare it to the mGFR. Bland-Altman plots, accuracy, and bias were utilized to evaluate theimportance of the eGFR readings. Findings: 94.20 mL/min/1.73 m2 was the median mGFR (interquartile range [IQR]: 88.40–100.50). The following were the eGFR values: 77.52 mL/min/1.73 m2 (IQR: 70.50–86.33) for CG; 76.14 mL/ min/1.73 m2 (IQR: 68.05–83.37) for MDRD; 106.80 ± 15.24 mL/min/1.73 m2 for CKD-EPI cystatin C 2012; 96.44 ± 13.40 mL/min/1.73 m2 for CKD-EPI creatinine 2012; 88.74 ± 13.27 mL/min/1.73 m2 for CKD-EPI creatinine 2021;and 101.32 ± 12.82 mL/min/1.73 m2 for creatinine cystatin C 2021 in CKD-EPI. The CKD-EPI creatinine cystatin C 2012 formula is one of these.(P30 = 98.96%) and 2021 (P30 = 97.92%) had the best agreement with the mGFR because of their narrow boundaries of agreement, minimal bias, and good accuracy in the Bland–Altman plots. Conclusions:For donor screening, the CKD-EPI equations based on creatinine and cystatin C are trustworthy resources.

Keywords:creatinine, cystatin C, glomerular filtration rate, kidney donation, living donors, and Vietnam

Citation:

Dr.Than Dep, The Precision Of Estimated Glomerular Filtration Rate Formulas In Prospective Living Kidney Donors From Vietnam. Journal of Clinical Transplantation 2025.