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Correspondence to Author: Shimaa Nour Morsi^1*, Ahmed Tawfeek², Ahmed Nagah Noureldin³, Eptehal M. Dongol⁴, and Doaa Gadallah¹. 

¹Department of Chest diseases, Faculty of Medicine, Sohag University, Egypt.
²Department of Clinical and chemical pathology, Faculty of Medicine, Sohag University, Egypt.
³Department of internal medicine, Faculty of Medicine, Sohag University, Egypt.
⁴Department of Chest diseases, Qena Faculty of Medicine, South Valley University, Egypt.

DOI: 10.52338/jrmr.2025.5218

Abstract:

Background: One prevalent complication of COPD is renal damage. Our objective is to examine the function of cystatin C and β2 microglobulin as indicators for detecting early kidney damage among older individuals with stable COPD and during exacerbations.
Methods: Prospective comparative cross-sectional study recruited 135 COPD cases, classified as 86 COPD cases with acute exacerbation (AECOPD) admitted to the respiratory department in Sohag University Hospital and 49 patients with stable COPD during the period from September 2023 to March 2024. Serum level of creatinine, cystatin C and B2 microglobulin were measured on admission.
Results: The mean age of the 85 male cases was 68.2i 4.51 years. Compared to stable COPD, AECOPD cases had considerably higher mean serum levels of β2 microglobulin and cystatin C (P value = 0.001 for both). A significant positive correlation was identified between β2 microglobulin and cystatin C (r= 0.539 and P value 0.001) and PaCO2 (r= 0.137 and P value 0.001) while a significant negative correlation with PaO2 (r= -0.785 and P value 0.001) in AECOPD. As regard cystatin C, there was significant positive correlation with β2 micro-globulin (r= 0.539 and P value 0.001) and PaCO2 (r= 0.003 and P value 0.001) while a significant negative correlation with PaO2 (r= -0.161and P-value = 0.045) in AECOPD.
Conclusion: Elderly individuals with AECOPD frequently experience acute kidney injury, which is positively correlated with the severity of hypoxemia and hypercapnia. Cys-C and β2-MG can be used as sensitive indicators to detect renal impairment early in older adults with AECOPD.

Keywords:Rigid bronchoscopy, Foreign body aspiration, Sapodilla seed, Elderly; Bronchial obstruction

Citation:

Doaa Gadallah, Early Detection Of Renal Injury In Elderly Patients With Chronic Obstructive Pulmonary Disease. Journal of Respiratory Medicine and Research 2025.