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Correspondence to Author: Sinclair Jonathan, Gareth Shadwell, Stephanie Dillon, Robert Allan, Bobbie Butters and Lindsay Bottoms. 

First Affiliated Hospital of Peking University, China.

Abstract: Cardiometabolic illness is the leading cause of global mortality and healthcare expense. Although pharmaceutical therapies are successful in the short term, their long-term efficacy is unclear and accompanying adverse effects are worrying. Montmorency tart cherries and blueberries contain significant quantities of anthocyanins, making them promising natural remedies for cardiometabolic disease. This project proposes a randomized controlled experiment to evaluate the impact of Montmorency tart cherry and blueberry juice on cardiometabolic outcomes compared to a placebo. This 20-day, parallel, single-blind, randomized, placebo-controlled experiment will enroll 45 participants.Participants will receive either 60 mL of Montmorency tart cherry juice, blueberry juice, or a placebo with a cherry/blueberry flavor. The study’s primary outcome is the difference in systolic blood pressure between groups at baseline and after intervention. Secondary outcome measures will include differences in anthropometrics, energy expenditure, substrate oxidation, haematology, blood pressure/resting heart rate, psychological well-being, and sleep efficacy. The statistical analysis will be done on an intention-to-treat basis. This study has received ethical approval from the University of Central Lancashire’s Health Research Ethics Committee (ref: HEALTH 0016) and is registered as a trial. The study’s findings will be published in a renowned peer-reviewed journal.

Citation:

Sinclair Jonathan. A 3-Arm Placebo Randomized Controlled Trial Was Conducted To Evaluate The Impact Of Montmorency Tart Cherry And Blueberry Juice On Cardiometabolic Outcomes In Healthy Individuals. Journal Of Energy Research 2025.