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• Research Article
• Open Access
• Thiago Augusto Rochetti Bezerra

Retinoblastoma is the most common malignant intraocular tumor of childhood, with important implications for the child’s survival and quality of life. Historically treated by enucleation and external radiotherapy, the management of the disease has evolved significantly with the advent of chemotherapy, which has become a more conservative and effective alternative.

• Review Article
• Open Access
• Gaurav Prakash

Lung cancer has a high prevalence and low survival rate in India due to patients presenting at late-stage. The National Cancer Control programs and Tobacco cessation programs are working to improve their diagnosis and management. However, there are no public health programs for Lung Cancer Screening in India.

• Review Article
• Open Access
• Gaurav Prakash

Circulating cell-free DNA (ccf-DNA) and circulating tumor DNA (ctDNA) provide a minimally invasive method for cancer detection and measurement. However, their diagnostic and prognostic significance in hematological malignancies remains ambiguous. This meta-analysis aims to evaluate the prognostic value of ccf-DNA or ctDNA in patients with diffuse large B-cell lymphoma (DLBCL).

• Review Article
• Open Access
• Zeeshan Abbas

As a mutation and genetics-dependent disease Prostate Cancer (PCa) ranks second among all male malignancies while remaining a dominant cause of male cancer fatalities. The BRCA1 and BRCA2 genes work to repair DNA but mutations in these genes make patients more vulnerable to tough types of PCa. BRCA2 mutations increase PCa risk four times more than other mutations including BRCA1 mutations.

• Review Article
• Open Access
• Danilo Coco MD

The management of pancreatic ductal adenocarcinoma (PDAC), particularly in the head of the pancreas, has evolved with the advent of minimally invasive surgical techniques. Robotic duodenopancreatectomy (RPD) and laparoscopic duodenopancreatectomy (LPD) have emerged as two promising approaches.

• Review Article
• Open Access
• Danli Wang

Lymphedema is a chronic and often debilitating condition affecting a significant number of breast cancer survivors. Beyond its physical manifestations, lymphedema has profound psychological and emotional implications, frequently overlooked in standard treatment protocols. This review aims to provide an in-depth understanding of the psychological and emotional challenges associated with lymphedema in breast cancer patients, emphasizing the need for comprehensive care that addresses both physical and mental health concerns.

• Research Article
• Open Access
• Agu Charles M

Breast cancer is a type of cancer with heterogeneous biology and is the leading cause of cancer-related mortality in women worldwide. This study aimed to establish breast cancer dynamics among breast cancer patients attending Niger Delta University Teaching Hospital Okolobiri. Archived Formalin fixed paraffin embedded breast tissues were retrieved and studied using hematoxylin and eosin staining, immunohistochemistry, and molecular methods.

• Research Article
• Open Access
• Cherupally Krishnan Krishnan Nair

The objective of this study is to compare preoperative and postoperative findings in patients diagnosed with endometrial hyperplasia, focusing on clinical symptoms, histopathological features, co-morbidities, surgical outcomes, and recurrence rates. This analysis aims to identify significant differences between hyperplasia with and without atypia, contributing to improved management strategies and clinical decision-making in patients undergoing treatment for endometrial hyperplasia.

• Research Article
• Open Access
• Bonucci M

Cancer patients are at high risk for acquiring PostTraumatic Stress Disorder (PTSD), but few research have evaluated the effectiveness of psychological therapies to treat it. Furthermore, it is understood that the presence of Unprocessed trauma prior to diagnosis increases the likelihood of developing PTSD.

• Research Article
• Open Access
• Lohynska Radka

Curative sphincter sparing radiation is a treatment option for early rectal cancer patients who do not qualify for drastic surgery.

• Commentary
• Open Access
• Gozzetti A

A plasma cell malignancy known as multiple myeloma (MM) is typified by several genetic abnormalities. It is possible to discriminate between two primary categories of abnormalities:

• Research Article
• Open Access
• Mark B Edelstein

Aggressive lymphoma and neurologic impairment have both been linked to HTLV-1. The retrovirus that causes adult human T-cell leukemia/lymphoma is called the Human T-cell Leukemia Virus Type 1.

• Commentary
• Open Access
• Christos K Kontos

Even with the last ten years’ worth of clinical advancements, clinical practice still lacks robust tumor biomarkers with higher sensitivity and specificity for specific malignancies.