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Correspondence to Author: Leart Svisson, Jooan Noigren. 

Chair and Department of Hygiene and Epidemiology,Medical University of Lublin, Poland b Doctoral School,Medical University of Lublin, Poland.

Abstract:

Historically, immortalized cells and animal models have been used to study human respiratory virus infections and pathogenesis. The intricate structure of the human airway and the entire range of illness symptoms seen in people, however, cannot be fully replicated by these models. Lung and nose organoids have recently transformed culture complexity in infection biology and shown promise for studying human respiratory viral infections. We discuss how developments in human nose and lung organoid models, which can express all respiratory epithelia cell types, including club, basal, goblet, and ciliated cells, have shed new light on the pathophysiology, age-dependent susceptibility, and viral attenuation signature.and defense mechanisms against respiratory viruses, including influenza, respiratory syncytial virus, and SARS-CoV-2. The models have also shown promise for researching human viruses that have not yet been cultivated and for assisting with zoonotic risk research.

Keywords: respiratory virus, human, lung, nose, stem cells, and organoids.

Citation:

Dr.Leart Svisson, New Developments In Organoid Models Of The Nose And Lung For Respiratory Viral Studies. World Journal Of Biology 2025.