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Correspondence to Author: Yong-Chan Kim and Byung-Hoon Jeong. 

Department of Stomatology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Abstract:

The human immunodeficiency virus (HIV) penetrates the host cell through CD4 and either CXC-chemokine receptor 4 (CXCR4) or CC-chemokine receptor 5 (CCR), which results in acquired immune deficiency syndrome (AIDS). Toll-like receptor 4 (TLR4) directly detects HIV and has downstream effects.signaling pathways linked to the immune system. Furthermore, the TLR4 gene’s rs4986790 single nucleotide polymorphism (SNP) (D299G) raises the likelihood of HIV-1 infection in the Indian population, and stimulated TLR4 prevents HIV-1 invasion. We gathered genetic data from HIV-1 patients in earlier research and conducted an association analysis with a matched control group sourced from the 1000 Genomes Project in order to assess whether the rs4986790 SNP of the TLR4 gene is linked to susceptibility to HIV-1 infection.We also conducted a meta-analysis to support the findings of association analysis. In earlier research, we found a substantial correlation between the rs4986791 SNP with HIV infection susceptibility in patients with HIV and a matched control.
The derived from the 1000 Genomes Project population. Furthermore, in a metaanalysis, we discovered that the G allele of the rs4986791 SNP in the TLR4 gene is highly associated with HIV infection susceptibility in all four populations (odd ratio = 2.22, 95% CI: 1.74–2.84, p = 2 × 10−10) and three Caucasian populations (odd ratio = 2.29, 95% CI: 1.72–3.07, p = 1.438 × 10−7). To the best of our knowledge, this was the first metaanalysis to examine the relationship between HIV infection susceptibility and the TLR4 gene’s rs4986791 SNP.

Keywords:HIV; susceptibility; TLR4; rs4986790; SNP; D299G; meta-analysis.

Citation:

Dr.Yong-Chan Kim, Strong Association Of The Rs4986790 Single Nucleotide Polymorphism (Snp) Of The TollLike Receptor 4 (Tlr4) Gene With Human Immunodeficiency Virus (Hiv) Infection:a MetaAnalysis. World Journal of Human Genetics 2025.