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Correspondence to Author:  Lourena Emanuele Costa^{1,2,3,+ *}, Gustavo Figueiredo Nunes Rabelo^{2,3, +}, Marcelo Braga Basílio⁴,Raphaela Mendes. 

⁺These authors contributed equally to this work
¹Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
²Afya Educação Médica. Departamento de Dermatologia Estética e Cosmiatria, São Paulo, 01424-000, São Paulo, Brazil.
³Instituto Mineiro de Cirurgia Plástica, IMCP, Belo Horizonte, 30112-020, Minas Gerais, Brazil.
⁴Faculdade de Saúde e Ecologia Humana, FASEH, Vespasiano, 32200-664, Minas Gerais, Brazil.

DOI: 10.52338/aods.2025.4628

Abstract:

Lipofilling , or facial fat grafting with autologous fat, has been widely used in aesthetic and reconstructive medicine due to its biocompatibility and regenerative potential. The technique, which consists of collecting, processing and reinjecting the patient's own fat, has evolved significantly in recent decades. However, challenges such as unpredictable graft reabsorption and variability in results still represent barriers to its wider application. This review critically analyzes recent advances in lipofilling , addressing best practices to maximize cell viability and graft longevity. Topics discussed include differences in harvesting methods (syringe-assisted suction vs. traditional liposuction), the influence of donor sites on graft quality, and purification techniques such as decantation, centrifugation, and filtration. In addition, the impact of adipose graft processing on cell survival is explored, emphasizing the importance of preserving the cellular microenvironment to optimize vascularization and tissue integration. Comparing lipofilling with emerging regenerative therapies, such as polydeoxyribonucleotide (PDRN) and exosomes , it is observed that these technologies can significantly enhance the effects of adipose grafting. Recent studies demonstrate that the combination of lipofilling with cellular biostimulators improves graft survival, reduces inflammation and promotes tissue regeneration, suggesting that these combined treatments can redefine the therapeutic standards of aesthetic medicine. The increasing incorporation of exosomes derived from mesenchymal stem cells and specific growth factors has shown promising results in maintaining graft quality and improving skin homeostasis. Although technological advances have allowed greater predictability in results, limitations still persist, such as the need for multiple sessions to achieve satisfactory volume and the difficulty in standardizing protocols to optimize the technique. Prospective studies and more robust clinical trials are needed to consolidate clinical guidelines and fully understand the mechanisms underlying the interaction between fat grafts and the recipient environment. In conclusion, lipofilling continues to play a central role in aesthetic medicine, with applications that go beyond volumization , encompassing tissue regeneration and biostimulation. The synergy between lipofilling and new therapeutic approaches, such as PDRN and exosomes , represents a promising milestone for the future of regenerative therapies, revolutionizing the way we address skin aging and facial volumetric restoration.

Citation:

Dr. Lourena Emanuele Costa, Revolution In Medical Aesthetics: The Role Of Lipofilling And Advanced Cellular Therapies. Annals of Dermatological Science 2025.