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Correspondence to Author:  Wioleta Stolare, 

Department of Pharmacology and Therapeutics 1 , Faculty of Medicine, Collegium Medicum, Nicolaus Copernicus University, 9 SklodowskiejCurie Street, Bydgoszcz, Poland.

Abstract:

Acetylsalicylic acid (ASA) is widely used as an antiplatelet therapeutic drug in secondary prevention. Despite its recognized benefits in treatment of subjects with cardiovascular (CV) diseases, last years brought many reports on ASA resistance or high-on treatment platelet reactivity (HTPR) despite aspirin treatment. The aim of this study is an evaluation of ASA resistance in long-term control basing on the result of arachidonic acidinduced platelet aggregation in reference to the results obtained during first 9 months of observation. This study is a prospective analysis with 30 subjects evaluated during control visit on average of 6,3 years after hospitalization from myocardial infarction. The examined population was divided into two subgroups according to the response to ASA. In order to estimate the function of blood platelets and their responsiveness to acetylsalicylic acid therapy, ASPI-test was used. The measurements were performed by the method of whole blood impedance aggregometry. During long-term visit significantly higher percentage of high platelet reactivity was observed, compared with previous visits (p=0.00001). Considering clinical endpoints of the research that were connected with coronary disease, no differences were obtained. The frequency of acetylsalicylic acid resistance in this study was higher than data reported in literature among subjects with CV diseases. In long-term observation the highest percentage of ASA non-responders was reported (58.6%), yet presence of ASA resistance did not affect the presence of the clinical endpoints for the study connected with coronary disease.

Keywords
Acetylsalicylic acid, Aspirin, Aspirin resistance, High-on treatment platelet reactivity, Myocardial infarction.

Citation:

Wioleta Stolarek Bydgoszcz. Acetylsalicylic acid resistance in long-term follow-up in subjects after myocardial infarction. Annals of Pharmacology and Pharmaceutical Sciences 2024.