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Correspondence to Author: Mishael N. Welder. 

Richard-Willstätter-Strasse 11, 12489 Berlin, Germany

Abstract:

A surprising percentage of seminal articles appear to be unreproducible by independent labs, per a number of recent investigations. An important part of this is played by nontherapeutic antibodies used for environmental, dietary, diagnostic, research, and other applications. issue. Even though several articles have been published with recommendations for how to make things better, they don’t seem to be thorough enough to address the intricacy of this problem in its entirety. Furthermore, there haven’t been any discernible advancements in the subject thus far. This article attempts to create a more cohesive idea by combining the astounding range of findings and recommended actions. It is determined that in order to address these issues and pave the path for a more sustainable approach to bioanalytical research that everyone can trust, funding organizations and journal publishers must act quickly.

Keywords: reproducibility crisis, irreproducibility, replication, paper retraction, peer review, immunochemistry, immunoassay, ligand binding assay, monoclonal antibody, quality control, cross-reactivity, non-specific binding, selectivity

Citation:

Dr.Mishael N. Welder, Quality Issues Of Research Antibodies.Journal of Antibodies 2025.