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Correspondence to Author: Hank Seoan Lee, Henry D. L. Wan, Arvinda Ponlusamy, Herelen Anderson, Raja kumar Chinnaldurai. 

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M1 7HR, UK.

Abstract:

One of the main causes of end-stage kidney disease worldwide, particularly in affluent nations, is diabetic nephropathy (DN). Microalbuminuria is a hallmark of the traditional pathogenic progression of DN, which leads to nephrotic-range proteinuria and renal function loss. In individuals with DN, the level of albuminuria is thought to be a separate risk factor for all-cause death. It is now commonly known that abnormalities in podocyte structure and function are the cause of albuminuria. A significant part of the glomerular filtration barrier is played by podocytes. Since the nephrin protein is a fundamental part of the podocyte’s slit diaphragm, it has been well documented that DN and other proteinuric glomerulopathies have downregulated nephrin expression. Prior research has demonstrated that urine nephrin may be an early indicator of podocyte damage in DN. The pathophysiology of podocytopathies may be influenced by circulating autoantibodies that target nephrin, according to a growing body of research in recent years. Nevertheless, nothing is known about the functional importance of these circulating autoantibodies in DN patients. Based on the literature currently available, we hope to assess the importance of nephrin dysregulation in the pathophysiology of DN in this review. We also hope to give a summary of the use of circulating anti-nephrin autoantibodies in relation to their diagnostic and prognostic role in podocytopathies, including DN.

Keywords: anti-nephrin; nephrin; diagnostic biomarker; prognostic biomarker; diabetes mellitus; diabetic nephropathy

Citation:

Dr.Hank Seoan Lee,Is There A Diagnostic And Prognostic Role For Anti-Nephrin Autoantibodies In Diabetic Nephropathy?. Journal of Antibodies 2025.