Author Login

Correspondence to Author:  Nazia Khursheed^*1, and Ramica Sharma^*1 

University school of Pharmaceutical sciences, Rayat-Bahra University, SAS Nagar, Punjab, 140103, Pharmacology, Kharar-SAS-Nagar, Mohali, India.

DOI: 10.52338/jotr.2024.4135

Abstract:

Many traditional medical systems employ herbal drugs for the hepatoprotection. Aim of the study was designed to evaluate the hepatoprotective potential of Tanacetum parthenium leaves against paracetamol (PCM) induced hepatotoxicity in wistar rats. Group -I animals were treated with 1ml CMC for 7 days. Group II to Group IV and V animals were administered with 1g/kg PCM for 7 days. In Group-II animals were treated with hepatotoxic drug Pcm (1g/kg) for 7 days, standard drug Silymarin (50mg/kg) was administered to Group-III for 7 days, Group-IV and Group-V were treated with (2mg/ kg) and (4mg/kg) Tanacetum parthenium respectively for 7 days. 24 hours after the last dosing by PCM the blood was collected through Retro-orbital sinus under light anesthesia and the animals were sacrificed. Hepatoprotective potential was assessed by various biochemical parameters such as SGOT, SGPT and Bilirubin. Group-V shows decreased level of biochemical parameters when compared with Group-IV. However, Significant attenuation in biochemical and oxidative stress parameters were observed in the Group-III. Results of the study were well supported by the histopathological observations. Thus, this study confirms that Parthenolides present in Tanacetum Parthenium possess hepatoprotective potential as comparable to that of the standard drug.

Citation:

Dr. Ramica Sharma. Antioxidant And Hepatoprotective Potential Of Tanacetum Parthenium In Pcm-Induced Experimental Hepatotoxicity. Journal of Toxicological Research 2024.