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Correspondence to Author: Dinesh Khadka¹, Sujan Shrestha², Sushil Dhakal³, Milan Adhikari⁴, Deepshikha Gaire⁵. 

¹Specialist Pathologist, Department of Pathology, Yasmed Medical Center Doha, Qatar.
²Assistant Professor, National Academy of Medical Sciences (NAMS), Bir Hospital, Nepal.
³Consultant Pathologist, Maya metro hospital, Dhangadi, Nepal.
⁴Assistant Professor, Nepalgunj Medical College Teaching Hospital, Nepalgunj, Nepal.
⁵Senior fellow histopathology, East and North Hertfordshire NHS Trust, London, England.

DOI: 10.52338/tjocp.2025.4975

Abstract:

Histoplasmosis most commonly occurs in immunocompromised patients, primarily affecting lungs. Isolated extra pulmonary manifestations are rare even in Human Immunodeficiency Virus (HIV) positive patients.
Case Description: A known HIV positive, 44 years Male patient presented to Out Patient Department with complains of pain abdomen, fever and loss of appetite for one and half months. On examination, multiple palpable tender nodes were seen in bilateral inguinal regions. USG Guided Fine Needle Aspiration Cytology (FNAC) ordered from the lymph node yielded pus like material. Chest radiograph was normal. Smears examined showed epithelioid cell granulomas along with plenty of extracellular as well as intracellular organisms showing morphological resemblance to Histoplasma species.
Conclusion: Though rare, a possibility of Histoplasma lymphadenitis should always be kept in mind even with normal chest radiographs in HIV patients presenting with lymphadenopathy. FNAC is a very simple, cheap and rapid procedure for diagnosing the same.

Keywords: : Fine Needle Aspiration Cytology, Histoplasmosis, HIV, Lymphadenopathy.

Citation:

Dinesh Khadka ,Histoplasmosis Presenting As Isolated Lymphadenopathy In HIV Positive Patient: A Case Report. The Journal of Clinical Pathology 2025.