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Correspondence to Author: Matheus Barros Lisboa¹, João Pedro Bampi Valmorbida², Bruno Giordano³, Felipe Mahfuz Correa⁴, Manuela Moreira Mota⁵, Ian Mazzetti Rodrigues Valle⁶, Lucas Gonçalves Zanini⁴, Igor Marijuschkin⁷, Felipe Campelo Lima Souza⁸  

¹Metropolitan University Center of the Amazon (UNIFAMAZ).
²Faceres School of Medicine.
³Pontifical Catholic University of São Paulo (PUC-SP).
⁴University of Mogi das Cruzes.
⁵Santo Amaro University (UNISA).
⁶Federal University of the São Francisco Valley Foundation (UNIVASF).
⁷Santos School of Medical Sciences; Residency in Orthopedics at the Brotherhood of Santa Casa da Misericórdia de Santos (ISCMS); Fellow in Foot and Ankle Surgery at Santa Casa de São Paulo.
⁸Integral Diferenciada College (FACID); Residency in Orthopedics at the Brotherhood of Santa Casa da Misericórdia de Santos (ISCMS); Fellow in Foot and Ankle Surgery at the ABC School of Medicine

DOI: 10.52338/tjop.2026.5795

Abstract:

Cartilage and osteochondral lesions of the talus associated with ankle fractures represent a major cause of chronic pain, functional limitation, and progressive joint degeneration. In this context, platelet-rich plasma (PRP) has been extensively investigated as a biological adjunct in the treatment of these lesions, due to its regenerative potential and ability to modulate the inflammatory response. The aim of this study was to conduct a systematic review of the literature on the use of PRP in talar chondral lesions associated with ankle fractures, analyzing its clinical, functional, radiographic, and biological effects. The methodology was conducted in accordance with the recommendations of the PRISMA 2020 protocol, with searches performed in the PubMed/MEDLINE, Scopus, Web of Science, Embase, Cochrane Library, SciELO, and BVS databases. Studies published between 2021 and 2026 involving patients who underwent PRP treatment alone or in combination with reconstructive surgical techniques were included. After applying the eligibility criteria, 47 studies were included in the qualitative synthesis. The results demonstrated that PRP provided significant benefits in pain reduction, functional improvement, and osteochondral regeneration, especially when combined with microfractures and bone marrow stimulation. The studies also showed improvement in radiographic findings and a favorable safety profile, with a low incidence of complications. However, significant methodological heterogeneity was observed among the studies, related to different formulations, platelet concentrations, and PRP application protocols. It is concluded that PRP represents a promising therapeutic strategy in the treatment of talar chondral lesions associated with ankle fractures, although high-quality randomized clinical trials are still needed to definitively establish its clinical efficacy

Keywords: Platelet-rich plasma; Osteochondral lesions of the talus; Ankle fractures; Regenerative orthopedics; Microfractures; Articular cartilage.

Citation:

Dr. Matheus Barros Lisboa, Systematic Review Of The Use Of PlateletRich Plasma In Chondral Injuries Of The Talus Associated With Ankle Fractures. The Journal of Orthopaedics 2026.